Identification by In Vivo Genomic Footprinting of a Transcriptional Switch Containing NF-kB and Sp1 That Regulates the IkBa Promoter
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W - KB Subunit - specific Regulation of the IKBCU Promoter *
Stimulation of endothelial cells by cytokines and bacterial lipopolysaccharide leads to activation f the transcription factor NF-KB. NF-KB in turn regulates the expression of several genes involved in the inflammatory reaction, including cell adhesion molecules, interleukins, and transcription factors. One of these induced genes encodes an inhibitor of NF-KB, ECI-~/IKB~, that contains in its 5‘...
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